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Decoding the gene regulatory logic of neuronal cell type specification

日期: 2018-10-19
2018年度秋季学期学术系列讲座之五
题目:Decoding the gene regulatory logic of neuronal cell type specification
讲座人:Oliver Hobert, Ph.D.
Investigator, Howard Hughes Medical Institute, 
Professor, Columbia University, New York, USA
时间:2018年10月19日(星期五),13:00-14:30
地点:澳门新浦京邓祐才报告厅 
摘要:
How are the many distinct cell types that characterize a mature nervous system genetically specified? For a terminally differentiating neuron this questions boils down to a gene regulatory question: how is the expression of the distinct batteries of genes that define the terminal, functional properties of distinct neuron type induced and maintained? Through the decoding of cis-regulatory elements and forward genetic screens in the nematode C.elegans, my laboratory has begun to uncover what appear to some simple, phylogenetically conserved principles that underlie the generation of diverse neuronal identities.
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